PH4S010 - Advanced Formulation Science 01 Apr 2025 - 31 Aug 2027 | Version 5
Associated Module Information
| Module Code: | PH4S010 | ||
|---|---|---|---|
| Module Title: | Advanced Formulation Science | ||
| Faculty: | Faculty of Computing, Engineering and Science | ||
| Faculty Group: | Chemical and Environmental Sciences | ||
| Faculty Sub Group: | Chemical and Environmental Sciences | ||
| Module Leader: | Andrew Graham | ||
| Module Team: | Natasha Galea, Suzanna Kean | ||
| First Intended Intake: | SEP 2015 | Final Year of Intake: | |
| Date Closed: | |||
| Credit Value: | 20 | Credit Level: | 7 |
| Language: | English | ||
| Percentage of Module Taught in Welsh: | 0 | ||
| Equivalent Module: | |||
| HECOS codes: | 100423 - pharmaceutical chemistry | ||
| HECOS Code Weighting: | 100 | ||
Document Version Information
| Version | 5 |
|---|---|
| Valid From | 01 Apr 2025 |
| Valid To | 31 Aug 2027 |
Module Aims
The aims of this module are to allow student to:-
1. Demonstrate a mechanistic understanding of the physical and chemical properties of disperse pharmaceutical systems .
2. Demonstrate both a qualitative and quantitative understanding of the behaviour of macromolecules in dispersion and in solution.
3. Critically evaluate the factors governing the choice of formulation components.
4. Formulate strategies to enhance the solubility/dispersibility of poorly soluble ingredients.
5. Investigate the interactions that influence the properties of a range of typical formulations.
Content Summary
Disperse Pharmaceutical Systems: (e.g, gels, suspensions, micellar/liposomal systems, aerosols, foams, solid dispersions, and emulsions (e.g., oil-in-water and water-in-oil emulsions, micro/macro-emulsions)).
Their properties: (e.g., Interfacial Properties, Interfacial free energy, Interfacial tension, Electrical Properties (zeta potential, absorption/desorption), flocculation, steric stabilization, Physical stability: including kinetics (Brownian motion, Diffusion, Sedimentation), Viscosity and flow.
The design of disperse systems: The typical components of the above formulations and their properties e.g., colloids and interfaces, colloidal stability and Derjaguin and Landau, Verwey and Overbeek (DVLO) theory. Ionic and non-ionic surfactants, the Hydrophilic/Lipophilic Balance (HLB), Adsorption of surfactants at interfaces, solubility enhancers, emulsifying agents. Their Judicial choice and subsequent manipulation to achieve desired properties (to design)for a required formulation.
Targeted Drug Delivery and Controlled release: introduction to polymer chemistry and its use in this context (block/random/alt polymers, micelles, emulsions) drug release mechanisms and stabilization.
The testing and characterisation of formulations.
The theory will be supported/enhanced by a range of practical lab based activities involving the making and testing of disperse
formulations.
Learning and Teaching Methods
| Activity Type | Hours |
|---|---|
| Lecture | 24 |
| Practical classes and workshops | 24 |
| Independent Study | 80 |
| Directed Study | 84 |
| Total Hours Selected | 212 |
Learning Outcomes
| # | Learning Outcome |
|---|---|
| LO1 | Reconcile the suitability of a disperse formulation within the context of its stability and suitability for purpose. |
| LO2 | Rationalise contributing factors/properties of the components of a disperse system and their influence on the design of disperse formulations. |
| LO3 | Design, characterise (either physically or by critical evaluation), and evaluate the properties of a disperse formulation. |
Module Requisites
N/A
Assessment Criteria
| Assessment Category | Assessment Type | Description | Duration | Word Count | Weight (%) | Best of? | Pass Mark |
|---|---|---|---|---|---|---|---|
| Synchronous Onsite Practical Assessment | Practical Coursework (Onsite) 1 | Ongoing written templated assessment demonstrating the application of practical skills and problem solving over a series of practical sessions. Assessment may be undertaken in groups (max 2) reflecting the nature of teams problem solving in the workplace. Students are expected to spend at least 1 hour on their assessment for every 1 hour spent undertaking the activity. | 0 | 2000 | 50 | No | 40 |
| Synchronous Online Assessment | Time-constrained assessment (Online) 1 | End of topic assignment via online delivery. | 0 | 2000 | 50 | No | 40 |
Assessment Matrix
| Assessment Type | Learning Outcomes | ||
|---|---|---|---|
| LO1 | LO2 | LO3 | |
| Practical Coursework (Onsite) 1 | ✔ | ✔ | ✔ |
| Time-constrained assessment (Online) 1 | ✔ | ✔ | ✔ |