PH3S58 - Advanced Drug Design and an Introduction to Formulation Science 01 Jul 2019 - 31 Jul 2029 | Version 3
Associated Module Information
| Module Code: | PH3S58 | ||
|---|---|---|---|
| Module Title: | Advanced Drug Design and an Introduction to Formulation Science | ||
| Faculty: | Faculty of Computing, Engineering and Science | ||
| Faculty Group: | Chemical and Environmental Sciences | ||
| Faculty Sub Group: | Chemical and Environmental Sciences | ||
| Module Leader: | Andrew Graham | ||
| Module Team: | Natasha Galea, Zi Mok, Rehana Karim, Julian Smith, Suzanna Kean | ||
| First Intended Intake: | SEP 2015 | Final Year of Intake: | |
| Date Closed: | |||
| Credit Value: | 20 | Credit Level: | 6 |
| Language: | English | ||
| Percentage of Module Taught in Welsh: | 0 | ||
| Equivalent Module: | |||
| HECOS codes: | 100423 - pharmaceutical chemistry | ||
| HECOS Code Weighting: | 100 | ||
Document Version Information
| Version | 3 |
|---|---|
| Valid From | 01 Jul 2019 |
| Valid To | 31 Jul 2029 |
Module Aims
1. To provide an understanding of the processes that industry uses to design drug candidates and the molecular science behind safe/effective drug administration (targeted delivery).
2. To introduce students to the new topics of computer modelling and polymer chemistry set in the context of this module.
3. To impart an appreciation of the practical difficulties in taking discoveries/syntheses from the laboratory scale to the bulk scale (scale up).
Content Summary
Computer aided design of drugs: introduction to computational chemistry, basic modelling techniques and its application to the pharmaceutical industry (QSAR).
Formulation studies: pharmaceuticals and medicines, pharmaceutical solutions, pH, solubility, the factors that affect the ability of the drug to still retain its activity yet be deliverable to its target organ/cell, pharmaceutical solid phase i.e. crystal polymorphism of pharmaceuticals and solid-state properties of powder particles.
Introduction to polymer chemistry and its use in this context (block/random/alt copolymers, micelles, emulsions), drug release mechanisms, and stabilization.
Process development: laboratory scale up, the factors that affect this.
Learning and Teaching Methods
| Activity Type | Hours |
|---|---|
| Lecture | 24 |
| Tutorial | 8 |
| Practical classes and workshops | 16 |
| Independent Study | 75 |
| Directed Study | 75 |
| Formative Assessment - Scheduled | 2 |
| Total Hours Selected | 200 |
Learning Outcomes
| # | Learning Outcome |
|---|---|
| LO1 | To critically evaluate the practical difficulties in taking discoveries/syntheses from the laboratory scale to the bulk scale (scale up). |
| LO2 | Critically evaluate the physicochemical properties of pharmaceutics for preformulation and formulation of medicines and demonstrate understanding of factors such as solubility, pH, polymorphism and particle size and their influence on bioavailability. Appreciate how polymers have impacted the discovery of novel therapeutics/and drug delivery vehicles. |
| LO3 | Develop specialist skills knowledge base encompassing molecular modelling theories. Utilise these specialist skills with regards to a range of chemical problems |
Module Requisites
| Code | Title | Requisite Type |
|---|---|---|
| MOD001555 | Heterocyclic Chemistry and an Introduction to Drug Design | pre-requisite |
Assessment Criteria
| Assessment Category | Assessment Type | Description | Duration | Word Count | Weight (%) | Best of? | Pass Mark |
|---|---|---|---|---|---|---|---|
| Portfolio | Portfolio 1 | A series of assessments that reflect the number of and varied nature of the modules contents in their application and output | 0 | 6000 | 100 | No | 40 |
Assessment Matrix
| Assessment Type | Learning Outcomes | ||
|---|---|---|---|
| LO1 | LO2 | LO3 | |
| Portfolio 1 | ✔ | ✔ | ✔ |