PH3S112 - From URS to PQ - A Practical Validation Strategy 01 Jan 2022 - 31 Aug 2028 | Version 1

Associated Module Information

Module Code: PH3S112
Module Title: From URS to PQ - A Practical Validation Strategy
Faculty: Faculty of Computing, Engineering and Science
Faculty Group: Applied Sciences
Faculty Sub Group: Chemistry and Pharmaceutical Science
Module Leader: Suzanna Kean
Module Team:
First Intended Intake: Final Year of Intake:
Date Closed:
Credit Value: 20 Credit Level: 6
Language: English
Percentage of Module Taught in Welsh: 0
Equivalent Module:
HECOS codes: 100078 - business and management 100144 - pharmaceutical engineering
HECOS Code Weighting: 50 50

Document Version Information

Version 1
Valid From 01 Jan 2022
Valid To 31 Aug 2028

Module Aims

The aim of this module is to give students an understanding of how to ensure that all user requirements are tested and verified from the beginning to the end of a typical project lifecycle. Students will also learn where in the project lifecycle that various testing should occur for the various equipment systems, with a view to optimizing resources and minimizing reworks / repeat testing, as well as practical ways to make these systems fit for handover to operations and maintenance

Content Summary

Indicative Syllabus:

• Planning the validation strategy
• Approaches for the qualification and commissioning for equipment systems
• Developing the traceability matrices
• Planning the protocol development and execution for multiple equipment systems
• Leveraging vendor testing activities both at the factory and on-site
• Post-construction and pre-commissioning tests
• Planning for handover of the project to plant operation and maintenance
• Preparing for the regulatory audit

This module is delivered through open/distance learning resource packs, pre-recorded lectures, problem-solving exercises and case studies.

Learning and Teaching Methods

Activity Type Hours
Independent Study 100
Directed Study 86
Formative Assessment - Independent 14
Total Hours Selected 200

Learning Outcomes

# Learning Outcome
LO1 Plan, schedule and manage a validation strategy over the entire lifecycle of a project, including the project handover to operations and preparation for the regulatory audit.
LO2 Generate the necessary URS and apply a range of risk-management tools to make regulatory based decisions about which equipment systems require commissioning and which require qualification, for the Facility and Equipment protocols.

Module Requisites

N/A

Assessment Criteria

Assessment Category Assessment Type Description Duration Word Count Weight (%) Best of? Pass Mark
Asynchronous Assessment Report 1 Develop the documents from P&IDs to PQ protocol for validating a multiple equipment system project 0 3000 100 No 40

Assessment Matrix

Assessment Type Learning Outcomes
LO1 LO2
Report 1

Reading List

Open distance/learning pack of materials resources

International Conference on Harmonisation (ICH) guidelines Q8, Q9, Q10, Q11

United States code of federal regulations online (www.fda.gov)

EU cGMPs Eudralex collection online ( http://pharmacos.eudra.org/F2/eudralex/vol-4/home.htm )

Pharmaceutical Inspection Convention / Co-operation Scheme (PIC/S) suite of regulatory guidelines and recommendations online (www.picscheme.org)

ISPE Baseline Guide 5 (Commissioning and Qualification);

ISPE Good Automated Manufacturing Practice (GAMP5)