PH2S107 - Commissioning & Qualification of Equipment and Systems 01 Jan 2022 - 31 Aug 2028 | Version 1

Associated Module Information

Module Code: PH2S107
Module Title: Commissioning & Qualification of Equipment and Systems
Faculty: Faculty of Computing, Engineering and Science
Faculty Group: Chemical and Environmental Sciences
Faculty Sub Group: Chemical and Environmental Sciences
Module Leader:
Module Team: Suzanna Kean
First Intended Intake: SEP 2023 Final Year of Intake:
Date Closed:
Credit Value: 20 Credit Level: 5
Language: English
Percentage of Module Taught in Welsh: 0
Equivalent Module:
HECOS codes: 100144 - pharmaceutical engineering
HECOS Code Weighting: 100

Document Version Information

Version 1
Valid From 01 Jan 2022
Valid To 31 Aug 2028

Module Aims

The aim is to define the testing requirements for a range of typical mechanical, process, instrumentation and automation systems used in the manufacture of medicinal products. This will range from standard good engineering practices (GEP), standard commissioning approaches, and specific regulatory focused qualification testing.

Content Summary

Indicative Syllabus:

• Interpreting P&IDs
• Traceability matrices: from URS to specifications, and from URS to PQ
• Equipment verification check sheets
• Instrument verification check sheets
• Piping verification check sheets
• Operational verification check sheets
• Defining the contents of IQ, and OQ protocols
• Populating a cleaning validation IOQ protocol

This module is delivered through open/distance learning resource packs, pre-recorded lectures, problem-solving exercises and case studies.

Learning and Teaching Methods

Activity Type Hours
Independent Study 100
Directed Study 64
Formative Assessment - Independent 36
Total Hours Selected 200

Learning Outcomes

# Learning Outcome
LO1 Prepare and execute validation testing protocols and qualify equipment, instruments and piping systems, along with automated systems.
LO2 Understand the design specifications used to generate testing scripts, and when and where testing scripts are needed during the project lifecycle.
LO3 Interpret Process & Instrumentation Diagrams (P&IDs).

Module Requisites

N/A

Assessment Criteria

Assessment Category Assessment Type Description Duration Word Count Weight (%) Best of? Pass Mark
Asynchronous Assessment Report 1 Assignment to complete the validation protocol for an equipment system including the population of IQ/OQ checksheets 0 3000 100 No 40

Assessment Matrix

Assessment Type Learning Outcomes
LO1 LO2 LO3
Report 1

Reading List

Open distance/learning pack of materials resources

Supplemental Reading:

International Conference on Harmonisation (ICH) guidelines Q8, Q9, Q10, Q11

United States code of federal regulations online (www.fda.gov)

EU cGMPs Eudralex collection online ( http://pharmacos.eudra.org/F2/eudralex/vol-4/home.htm )

Pharmaceutical Inspection Convention / Co-operation Scheme (PIC/S) suite of regulatory guidelines and recommendations online (www.picscheme.org)

ISPE Baseline Guide 5 (Commissioning and Qualification)

ISPE Good Automated Manufacturing Practice (GAMP5)