PH3S114 - Medicinal Drug Design 01 Sep 2023 - 31 Aug 2029 | Version 1
Associated Module Information
| Module Code: | PH3S114 | ||
|---|---|---|---|
| Module Title: | Medicinal Drug Design | ||
| Faculty: | Faculty of Computing, Engineering and Science | ||
| Faculty Group: | Applied Sciences | ||
| Faculty Sub Group: | Chemistry and Forensics | ||
| Module Leader: | Andrew Graham | ||
| Module Team: | Natasha Galea | ||
| First Intended Intake: | SEP 2028 | Final Year of Intake: | 2028 |
| Date Closed: | |||
| Credit Value: | 20 | Credit Level: | 6 |
| Language: | English | ||
| Percentage of Module Taught in Welsh: | 0 | ||
| Equivalent Module: | |||
| HECOS codes: | 100358 - applied computing | 100420 - medicinal chemistry | 100423 - pharmaceutical chemistry |
| HECOS Code Weighting: | 20 | 60 | 20 |
Document Version Information
| Version | 1 |
|---|---|
| Valid From | 01 Sep 2023 |
| Valid To | 31 Aug 2029 |
Module Aims
1. To provide an understanding of the processes that industry uses to design drug candidates, drug action and synthesis, and the molecular science behind safe/effective drug administration (targeted delivery).
2. To impart an appreciation of the practical difficulties in taking discoveries/syntheses from the laboratory scale to the bulk scale (scale up).
3. To introduce students to the new topics of computer modelling and polymer chemistry set in the context of this module.
Content Summary
1) Drug Discovery and Design
The development of active pharmaceutical ingredients pharmaceuticals and future directions of small molecule drug discovery. Basic structural requirements for pharmaceutical activity (Lipinski rule of 5) including physicochemical, stereoisomeric and electronic properties of drug molecules and intermolecular forces. Drug targets including drug receptors, enzymes and non-specific interactions. Fundamentals of pharmacokinetics and pharmacodynamics including partitioning of drugs and drug transport and routes of administration. Basic drug design, development and lead compound identification. Fundamentals of structure-activity relationships and quantitative structure-activity relationships including case studies on the design and development of salbutamol, propranolol and cimetidine. Inflammatory and analgesic drugs; antifungal and antibiotic drugs.
Process development: laboratory scale up, the factors that affect this
Computer aided design of drugs: introduction to computational chemistry, basic modelling techniques and its application to the pharmaceutical industry (QSAR).
Learning and Teaching Methods
| Activity Type | Hours |
|---|---|
| Lecture | 24 |
| Tutorial | 8 |
| Practical classes and workshops | 16 |
| Independent Study | 75 |
| Directed Study | 75 |
| Formative Assessment - Scheduled | 2 |
| Total Hours Selected | 200 |
Learning Outcomes
| # | Learning Outcome |
|---|---|
| LO1 | Apply diagnostic and creative skills to review?fundamental aspects of medicinal and pharmaceutical chemistry and demonstrate knowledge of basic drug design, development and lead compound identification. |
| LO2 | To critically evaluate the practical difficulties in taking discoveries/syntheses from the laboratory scale to the bulk scale (scale up). |
| LO3 | Develop specialist skills knowledge base encompassing molecular modelling theories. Utilise these specialist skills with regards to a range of chemical problems |
Module Requisites
| Code | Title | Requisite Type |
|---|---|---|
| MOD012491 | Introduction to Formulation Science and Pharmaceutical Analysis | pre-requisite |
Assessment Criteria
| Assessment Category | Assessment Type | Description | Duration | Word Count | Weight (%) | Best of? | Pass Mark |
|---|---|---|---|---|---|---|---|
| Asynchronous Assessment | Practical Written Work 1 | Practical write ups following laboratory sessions | 0 | 2000 | 50 | No | 40 |
| Asynchronous Assessment | Portfolio 1 | Written assignments on topics covered in the module Written assignment encompassing the drug design and development Written assignment encompassing the topic of drug formulation. | 0 | 2000 | 50 | No | 40 |
Assessment Matrix
| Assessment Type | Learning Outcomes | ||
|---|---|---|---|
| LO1 | LO2 | LO3 | |
| Practical Written Work 1 | ✔ | ✔ | ✔ |
| Portfolio 1 | ✔ | ✔ | ✔ |